What Is VDR?

VDR is a gene which encodes for a protein which acts as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene, the rs2228570 (FokI polymorphism) is associated with lower bone mineral density in white prepubertal girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern, as well as the time off-and-on occupancy of the VDRE between the two components. It is also affected by chromosomal positioning and binding preferences for specific hormones. Microarray studies of human cells show that more than 100 genes possess a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence https://www.gescheftmarketing.de/2021/09/01/how-much-icloud-storage-do-you-really-need/ of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) can be an archive of data and documents that are relevant to legal, business transactions or processes. Viewing, downloading, and printing are all restricted. It makes use of central computers and an extranet, which is a restricted-access Internet connection, allowing users to log in at specified times.

VDRs are most commonly used by investment banks and companies involved in mergers and acquisitions. They need to be able to communicate information in a clear manner with potential investors or buyers. The due diligence process can also require a substantial amount of data. Life science companies also use VDRs to keep everything from clinical trials results to HIPAA documentation.